Assay Detail
Functional
CHEMBL617041
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Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.92 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83426 | — | — | 1 | 9.30 |
| CHEMBL420965 | — | — | 1 | 9.10 |
| CHEMBL85668 | — | — | 1 | 8.92 |
| CHEMBL84712 | — | — | 1 | 8.72 |
| CHEMBL82204 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83426 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL420965 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL85668 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL84712 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL82204 | — | EC50 | = | 2.9 | nM | 8.54 |