Assay Detail
Functional
CHEMBL617042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 8.53 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 9.35 |
| CHEMBL333341 | — | — | 1 | 9.05 |
| CHEMBL420965 | — | — | 1 | 9.03 |
| CHEMBL313714 | — | — | 1 | 8.96 |
| CHEMBL331970 | — | — | 1 | 8.82 |
| CHEMBL117579 | — | — | 1 | 8.80 |
| CHEMBL304857 | — | — | 1 | 8.80 |
| CHEMBL118012 | — | — | 1 | 8.74 |
| CHEMBL326371 | — | — | 1 | 8.68 |
| CHEMBL116092 | — | — | 1 | 8.59 |
| CHEMBL159819 | — | — | 1 | 8.39 |
| CHEMBL117046 | — | — | 1 | 8.10 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 8.08 |
| CHEMBL420874 | — | — | 2 | 7.82 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL333341 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL420965 | — | EC50 | = | 0.93 | nM | 9.03 |
| CHEMBL313714 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL331970 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL117579 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL304857 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL118012 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL326371 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL116092 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL159819 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL117046 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL905 | RIZATRIPTAN | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL420874 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL420874 | — | EC50 | = | 33.0 | nM | 7.48 |