Assay Detail
Binding
CHEMBL617091
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Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.68 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160581 | — | — | 1 | 9.02 |
| CHEMBL421064 | — | — | 1 | 8.92 |
| CHEMBL352234 | — | — | 1 | 8.70 |
| CHEMBL120055 | — | — | 1 | 8.68 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160581 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL421064 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL352234 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL120055 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 8.5 | nM | 8.07 |