Assay Detail
Functional
CHEMBL617094
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Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.55 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143512 | — | — | 1 | 7.72 |
| CHEMBL143767 | — | — | 1 | 7.52 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.52 |
| CHEMBL143967 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143512 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL143767 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL143967 | — | Ki | = | 36.0 | nM | 7.44 |