Assay Detail
Binding
CHEMBL617154
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Binding affinity at 5-hydroxytryptamine 2 receptor by the inhibition of binding to [3H]ketanserin in rat cortical membranes
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
New indole derivatives as potent and selective serotonin uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.10 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281808 | — | — | 1 | 10.30 |
| CHEMBL19613 | — | — | 1 | 9.15 |
| CHEMBL19111 | — | — | 1 | 8.89 |
| CHEMBL19267 | — | — | 1 | 8.55 |
| CHEMBL19203 | — | — | 1 | 8.40 |
| CHEMBL416544 | — | — | 1 | 8.40 |
| CHEMBL274517 | — | — | 1 | 8.37 |
| CHEMBL18224 | — | — | 1 | 8.22 |
| CHEMBL279414 | — | — | 1 | 8.22 |
| CHEMBL19652 | — | — | 1 | 7.96 |
| CHEMBL19347 | — | — | 1 | 7.85 |
| CHEMBL18512 | — | — | 1 | 7.80 |
| CHEMBL275354 | — | — | 1 | 7.64 |
| CHEMBL429768 | — | — | 1 | 7.60 |
| CHEMBL18625 | — | — | 1 | 7.57 |
| CHEMBL274728 | RP-68303 | — | 1 | 7.52 |
| CHEMBL18212 | — | — | 1 | 7.35 |
| CHEMBL19051 | — | — | 1 | 7.14 |
| CHEMBL19226 | — | — | 1 | 7.00 |
| CHEMBL19270 | — | — | 1 | - |
| CHEMBL276922 | — | — | 1 | - |
| CHEMBL414187 | — | — | 1 | - |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | - |
| CHEMBL19335 | — | — | 1 | - |
| CHEMBL19228 | — | — | 1 | - |
| CHEMBL276565 | — | — | 1 | - |
| CHEMBL18501 | — | — | 1 | - |
| CHEMBL276920 | — | — | 1 | - |
| CHEMBL278080 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281808 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL19613 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL19111 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL19267 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL19203 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL416544 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL274517 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL18224 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279414 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL19652 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL19347 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL18512 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL275354 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL429768 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL18625 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL274728 | RP-68303 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL18212 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL19051 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL19226 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL19270 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL276922 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL414187 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL41 | FLUOXETINE | IC50 | > | 100.0 | nM | - |
| CHEMBL19335 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL19228 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL276565 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL18501 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL276920 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL278080 | — | IC50 | > | 100.0 | nM | - |