Compound Detail
CHEMBL274728
RP-68303 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL274728 |
| Name | RP-68303 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZUSTSFFNOEAHE-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
468.6
MW (Da)
4.08
ALogP
3
HBA
1
HBD
59.6
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 1 (5-HT1) receptor CHEMBL2095159 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Serotonin 2 (5-HT2) receptor CHEMBL2093870 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | IC50 | = | 1.2 | nM | 8.92 | Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inh... | 8487257 |
| Serotonin 1 (5-HT1) receptor | IC50 | = | 1.2 | nM | 8.92 | Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to... | - |
| Serotonin 2 (5-HT2) receptor | IC50 | = | 30.0 | nM | 7.52 | Binding affinity at 5-hydroxytryptamine 2 receptor by the inhibition of binding ... | 8487257 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8487257 | 10.1021/jm00061a010 | Mus musculus | 4 |
| - | 10.1016/S0960-894X(01)80986-0 | Mus musculus | 2 |
| 8487257 | 10.1021/jm00061a010 | Sodium-dependent serotonin transporter | 1 |
| 8487257 | 10.1021/jm00061a010 | Serotonin 2 (5-HT2) receptor | 1 |
| 8487257 | 10.1021/jm00061a010 | Adrenergic receptor alpha-1 | 1 |
| 8487257 | 10.1021/jm00061a010 | D(2) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(01)80986-0 | Serotonin 1 (5-HT1) receptor | 1 |
Data from ChEMBL 36 via Core Engine