Serotonin 1 (5-HT1) receptor · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P28564. Use UniProt P28564 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28564 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 1B
Review this target as Serotonin 1 (5-HT1) receptor, mapped to UniProt P28564. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 1B. Sequence length is 386 aa.
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This review treats Serotonin 1 (5-HT1) receptor as ChEMBL target CHEMBL2095159, mapped to UniProt P28564. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serotonin 1 (5-HT1) receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P28564 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1B |
| UniProt Accession | P28564 |
| Component Type | Protein |
| Sequence Length | 386 aa |
5-hydroxytryptamine receptor 1B
Review this target as Serotonin 1 (5-HT1) receptor, mapped to UniProt P28564. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 1B. Sequence length is 386 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL300585 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL57483 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL294425 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL274728 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL57506 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL60640 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL18785 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL39 | 8.7 | Ki | 2.0 | Clinical |
| CHEMBL8165 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL299917 | 8.68 | IC50 | 2.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 27 | 80 | 6.7 |
| protein format | 24 | 42 | 6.8 |
| cell membrane format | 6 | 38 | 7.9 |
| assay format | 5 | 48 | 6.3 |
| subcellular format | 1 | 59 | 5.9 |