Evidence Snapshot

Serotonin 1 (5-HT1) receptor

CHEMBL2095159 PROTEIN FAMILY Rattus norvegicus

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:24:23Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 4:24 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL2095159

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serotonin 1 (5-HT1) receptor as ChEMBL target CHEMBL2095159, mapped to UniProt P28564. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Serotonin 1 (5-HT1) receptor

PROTEIN FAMILY · Rattus norvegicus

As of 2026-09-13

ChEMBL target ID

CHEMBL2095159

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P28564

5-hydroxytryptamine receptor 1B

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Serotonin 1 (5-HT1) receptor matters

As of 2026-09-13

Serotonin 1 (5-HT1) receptor is reviewed as 5-hydroxytryptamine receptor 1B (UniProt P28564); the current evidence base includes 16 approved drugs, 372 compounds, and 63 assays, with lead potency reaching pChEMBL 9.3.

Protein context

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B Sequence length is 386 aa.

Review this target as Serotonin 1 (5-HT1) receptor, mapped to UniProt P28564. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 1B. Sequence length is 386 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P28564 Protein

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 16 approved drugs, 372 compounds, and 63 assays for this target. The dominant activity type is IC50. CHEMBL300585 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL300585 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine

16 approved pChEMBL 9.3

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Serotonin 1 (5-HT1) receptor matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P28564, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

372

Total Compounds

Total Assays

Approved Drugs

IC50: 209.0, KI: 155.0, KD: 8.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL300585	9.3	IC50	—
No preferred name CHEMBL57483	9.0	IC50	—
No preferred name CHEMBL294425	9.0	IC50	—
No preferred name CHEMBL274728	8.9	IC50	—
No preferred name CHEMBL57506	8.8	IC50	—