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Assay Detail

CHEMBL617205

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against serotonin 5-hydroxytryptamine 2 receptor from mice.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin 2 (5-HT2) receptor (CHEMBL2096671)
Type PROTEIN FAMILY
Organism Mus musculus

Publication

Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents.
Norman MH, Navas F, Thompson JB, Rigdon GC.
J Med Chem (1996) 39 : 4692 -4703
PubMed 8941382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 8.72 9.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL141319 1 9.54
CHEMBL343838 1 9.46
CHEMBL142850 1 9.07
CHEMBL343228 1 8.92
CHEMBL142456 1 8.89
CHEMBL141438 1 8.89
CHEMBL344994 1 8.82
CHEMBL141392 1 8.82
CHEMBL85 RISPERIDONE 4.0 1 8.82
CHEMBL143447 1 8.82
CHEMBL141494 1 8.64
CHEMBL141485 1 8.64
CHEMBL356743 1 8.62
CHEMBL358268 1 8.62
CHEMBL143075 1 8.60
CHEMBL356498 1 8.54
CHEMBL342742 1 8.51
CHEMBL142277 1 8.47
CHEMBL142211 1 8.08
CHEMBL42 CLOZAPINE 4.0 1 7.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL141319 IC50 = 0.29 nM 9.54
CHEMBL343838 IC50 = 0.35 nM 9.46
CHEMBL142850 IC50 = 0.85 nM 9.07
CHEMBL343228 IC50 = 1.2 nM 8.92
CHEMBL142456 IC50 = 1.3 nM 8.89
CHEMBL141438 IC50 = 1.3 nM 8.89
CHEMBL344994 IC50 = 1.5 nM 8.82
CHEMBL141392 IC50 = 1.5 nM 8.82
CHEMBL85 RISPERIDONE IC50 = 1.5 nM 8.82
CHEMBL143447 IC50 = 1.5 nM 8.82
CHEMBL141494 IC50 = 2.3 nM 8.64
CHEMBL141485 IC50 = 2.3 nM 8.64
CHEMBL356743 IC50 = 2.4 nM 8.62
CHEMBL358268 IC50 = 2.4 nM 8.62
CHEMBL143075 IC50 = 2.5 nM 8.60
CHEMBL356498 IC50 = 2.9 nM 8.54
CHEMBL342742 IC50 = 3.1 nM 8.51
CHEMBL142277 IC50 = 3.4 nM 8.47
CHEMBL142211 IC50 = 8.3 nM 8.08
CHEMBL42 CLOZAPINE IC50 = 28.0 nM 7.55