Assay Detail
Binding
CHEMBL617210
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In vitro binding affinity for serotonin 5-hydroxytryptamine (5-HT) 2 receptors
104
Total Activities
104
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel piperidine sigma receptor ligands as potential antipsychotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 104 | 6.83 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136794 | — | — | 1 | 8.48 |
| CHEMBL136064 | — | — | 1 | 8.44 |
| CHEMBL138281 | — | — | 1 | 8.22 |
| CHEMBL134527 | — | — | 1 | 8.10 |
| CHEMBL139963 | — | — | 1 | 8.08 |
| CHEMBL335327 | — | — | 1 | 8.05 |
| CHEMBL337337 | — | — | 1 | 8.00 |
| CHEMBL544616 | — | — | 1 | 7.92 |
| CHEMBL543412 | — | — | 1 | 7.82 |
| CHEMBL136615 | — | — | 1 | 7.82 |
| CHEMBL136509 | — | — | 1 | 7.77 |
| CHEMBL342267 | — | — | 1 | 7.70 |
| CHEMBL137085 | — | — | 1 | 7.62 |
| CHEMBL136963 | — | — | 1 | 7.62 |
| CHEMBL545552 | — | — | 1 | 7.60 |
| CHEMBL555865 | — | — | 1 | 7.58 |
| CHEMBL136768 | — | — | 1 | 7.58 |
| CHEMBL539358 | — | — | 1 | 7.55 |
| CHEMBL136381 | — | — | 1 | 7.51 |
| CHEMBL540322 | — | — | 1 | 7.50 |
| CHEMBL136835 | — | — | 1 | 7.42 |
| CHEMBL539302 | — | — | 1 | 7.40 |
| CHEMBL538532 | — | — | 1 | 7.39 |
| CHEMBL136701 | — | — | 1 | 7.39 |
| CHEMBL137658 | — | — | 1 | 7.33 |
| CHEMBL139110 | — | — | 1 | 7.28 |
| CHEMBL137159 | — | — | 1 | 7.26 |
| CHEMBL136622 | — | — | 1 | 7.19 |
| CHEMBL543439 | — | — | 1 | 7.06 |
| CHEMBL136621 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136794 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL136064 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL138281 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL134527 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL139963 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL335327 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL337337 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL544616 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL136615 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL543412 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL136509 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL342267 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL137085 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL136963 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL545552 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL136768 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL555865 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL539358 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL136381 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL540322 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL136835 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL539302 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL136701 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL538532 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL137658 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL139110 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL137159 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL136622 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL543439 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL136621 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL423355 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL545549 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL342948 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL440345 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL542737 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL542246 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL424281 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL543440 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL539042 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL337148 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL136789 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL136395 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL554678 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL542740 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL337810 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL540578 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL136495 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL543917 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL539567 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL442965 | — | Ki | = | 290.0 | nM | 6.54 |