Assay Detail
Binding
CHEMBL617213
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Binding affinity for porcine 5-hydroxytryptamine 2 receptor using [3H]- ketanserin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.75 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124444 | — | — | 1 | 6.18 |
| CHEMBL337531 | — | — | 1 | 6.14 |
| CHEMBL59725 | — | — | 1 | 5.70 |
| CHEMBL139926 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124444 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL337531 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL59725 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL139926 | — | Ki | = | 11000.0 | nM | 4.96 |