Assay Detail
Binding
CHEMBL617214
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Binding affinity for porcine 5-hydroxytryptamine 2 receptor using [3H]- ketanserin with 10 uM prazosin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.03 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424294 | — | — | 1 | 6.46 |
| CHEMBL141419 | — | — | 1 | 6.30 |
| CHEMBL342060 | — | — | 1 | 6.13 |
| CHEMBL25236 | BP-897 | — | 1 | 6.08 |
| CHEMBL336930 | — | — | 1 | 6.02 |
| CHEMBL142020 | — | — | 1 | 5.92 |
| CHEMBL423735 | — | — | 1 | 5.89 |
| CHEMBL143352 | — | — | 1 | 5.80 |
| CHEMBL344677 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424294 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL141419 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL342060 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL25236 | BP-897 | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL336930 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL142020 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL423735 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL143352 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL344677 | — | Ki | = | 2000.0 | nM | 5.70 |