Assay Detail
Binding
CHEMBL617253
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Binding affinity to human cloned 5-hydroxytryptamine 2A receptor in HEK 293 cells using [3H]- ketanserin as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.10 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97637 | — | — | 1 | 6.30 |
| CHEMBL316081 | — | — | 1 | 6.00 |
| CHEMBL97596 | — | — | 1 | 6.00 |
| CHEMBL261917 | — | — | 1 | - |
| CHEMBL97211 | — | — | 1 | - |
| CHEMBL97158 | — | — | 1 | - |
| CHEMBL318018 | — | — | 1 | - |
| CHEMBL98965 | — | — | 1 | - |
| CHEMBL95823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97637 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL316081 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL97596 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL261917 | — | Ki | < | 3162.28 | nM | - |
| CHEMBL97211 | — | Ki | < | 1995.26 | nM | - |
| CHEMBL97158 | — | Ki | < | 2511.89 | nM | - |
| CHEMBL318018 | — | Ki | < | 1995.26 | nM | - |
| CHEMBL98965 | — | Ki | < | 1258.93 | nM | - |
| CHEMBL95823 | — | Ki | < | 2511.89 | nM | - |