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Compound Detail

CHEMBL97637

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O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc(-c2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL97637
Phase Preclinical
Structure Type MOL
InChI Key PMKGXTGSQFTEEH-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

444.6
MW (Da)
4.11
ALogP
5
HBA
2
HBD
74.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H24N4O2S
MW 444.56
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.33

Activity Summary

Ki 6 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 6
CHEMBL3371
Ki 9.3 9.3 0.5 2
5-hydroxytryptamine receptor 1D
CHEMBL1983
Ki 6.8 6.8 158.5 1
5-hydroxytryptamine receptor 1B
CHEMBL1898
Ki 6.5 6.5 316.2 1
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 6.3 6.3 501.2 1
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 6.2 6.2 631.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 6 2
11597412 10.1016/s0960-894x(01)00558-3 Unchecked 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 1A 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 1B 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 1D 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 2A 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 2B 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 2C 1
11597412 10.1016/s0960-894x(01)00558-3 5-hydroxytryptamine receptor 7 1
11597412 10.1016/s0960-894x(01)00558-3 D(2) dopamine receptor 1
11597412 10.1016/s0960-894x(01)00558-3 D(3) dopamine receptor 1

Data from ChEMBL 36 via Core Engine