Assay Detail
Binding
CHEMBL617304
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Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.86 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203216 | — | — | 1 | 9.59 |
| CHEMBL121207 | — | — | 1 | 9.47 |
| CHEMBL120514 | — | — | 1 | 9.42 |
| CHEMBL334323 | — | — | 1 | 9.38 |
| CHEMBL121901 | — | — | 1 | 9.25 |
| CHEMBL332142 | — | — | 1 | 9.24 |
| CHEMBL119927 | — | — | 1 | 9.04 |
| CHEMBL1185 | ZOLMITRIPTAN | 4.0 | 1 | 9.04 |
| CHEMBL121499 | — | — | 1 | 9.03 |
| CHEMBL117157 | — | — | 1 | 9.00 |
| CHEMBL421064 | — | — | 1 | 8.92 |
| CHEMBL120272 | — | — | 1 | 8.92 |
| CHEMBL331037 | — | — | 1 | 8.89 |
| CHEMBL116314 | — | — | 1 | 8.85 |
| CHEMBL331240 | — | — | 1 | 8.85 |
| CHEMBL334193 | — | — | 1 | 8.77 |
| CHEMBL120480 | — | — | 1 | 8.74 |
| CHEMBL120055 | — | — | 1 | 8.68 |
| CHEMBL324289 | — | — | 1 | 8.60 |
| CHEMBL334159 | — | — | 1 | 8.54 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.32 |
| CHEMBL332063 | — | — | 1 | 8.16 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.07 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203216 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL121207 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL120514 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL334323 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL121901 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL332142 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL119927 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL1185 | ZOLMITRIPTAN | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL121499 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL117157 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL421064 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL120272 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL331037 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL116314 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL331240 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL334193 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL120480 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL120055 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL324289 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL334159 | — | Ki | = | 2.92 | nM | 8.54 |
| CHEMBL39 | SEROTONIN | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL332063 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL905 | RIZATRIPTAN | Ki | = | 13.5 | nM | 7.87 |