Assay Detail
Binding
CHEMBL617305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.70 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788197 | — | — | 1 | 9.05 |
| CHEMBL1744040 | — | — | 1 | 8.80 |
| CHEMBL72062 | — | — | 1 | 8.70 |
| CHEMBL70680 | — | — | 1 | 8.70 |
| CHEMBL306197 | — | — | 1 | 8.60 |
| CHEMBL304767 | — | — | 1 | 8.55 |
| CHEMBL305837 | — | — | 1 | 8.47 |
| CHEMBL1788198 | — | — | 1 | 8.30 |
| CHEMBL303921 | — | — | 1 | 8.29 |
| CHEMBL1744039 | — | — | 1 | 8.19 |
| CHEMBL72285 | — | — | 1 | 8.13 |
| CHEMBL423127 | — | — | 1 | 8.01 |
| CHEMBL413105 | — | — | 1 | 7.92 |
| CHEMBL420748 | — | — | 1 | 7.89 |
| CHEMBL71145 | — | — | 1 | 7.89 |
| CHEMBL303339 | — | — | 1 | 7.82 |
| CHEMBL71469 | — | — | 1 | 7.80 |
| CHEMBL302172 | — | — | 1 | 7.80 |
| CHEMBL1788196 | — | — | 1 | 7.72 |
| CHEMBL71640 | — | — | 1 | 7.62 |
| CHEMBL69943 | — | — | 1 | 7.58 |
| CHEMBL312525 | — | — | 1 | 7.57 |
| CHEMBL420191 | — | — | 1 | 7.48 |
| CHEMBL1744041 | — | — | 1 | 7.46 |
| CHEMBL309121 | — | — | 1 | 7.46 |
| CHEMBL65196 | — | — | 1 | 7.41 |
| CHEMBL70980 | — | — | 1 | 7.20 |
| CHEMBL305976 | — | — | 1 | 7.16 |
| CHEMBL69729 | — | — | 1 | 7.12 |
| CHEMBL69560 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788197 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1744040 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL70680 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL72062 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL306197 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL304767 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL305837 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL1788198 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL303921 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL1744039 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL72285 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL423127 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL413105 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL420748 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL71145 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL303339 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL71469 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL302172 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1788196 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL71640 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL69943 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL312525 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL420191 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL309121 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1744041 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL65196 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL70980 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL305976 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL69729 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL69560 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL71409 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL70606 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL292274 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL2112317 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL73112 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL302171 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL70970 | — | Ki | - | nM | - | |
| CHEMBL308934 | — | Ki | - | nM | - | |
| CHEMBL307786 | — | Ki | - | nM | - | |
| CHEMBL306198 | — | Ki | - | nM | - | |
| CHEMBL304426 | — | Ki | - | nM | - | |
| CHEMBL71625 | — | Ki | - | nM | - | |
| CHEMBL1788200 | — | Ki | - | nM | - | |
| CHEMBL304984 | — | Ki | - | nM | - | |
| CHEMBL70489 | — | Ki | - | nM | - |