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Assay Detail

CHEMBL617366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for the binding affinity against the site labelled by the 5-hydroxytryptamine 2A receptor - 5-hydroxytryptamine 2C receptor antagonist [3H] ketanserin
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (CHEMBL2111383)
Type SELECTIVITY GROUP
Organism Rattus norvegicus

Publication

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF.
J Med Chem (1994) 37 : 4346 -4351
PubMed 7996545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.13 7.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL136354 1 7.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL136354 Ki = 74.5 nM 7.13