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Assay Detail

CHEMBL617486

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligand
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA.
J Med Chem (2003) 46 : 4188 -4195
PubMed 12954071 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.19 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL134519 1 9.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL134519 Ki = 0.65 nM 9.19