Assay Detail
Binding
CHEMBL617499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for the binding affinity against 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.90 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 8.80 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.50 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.50 |
| CHEMBL342690 | — | — | 1 | 6.00 |
| CHEMBL136108 | — | — | 1 | 5.70 |
| CHEMBL136978 | — | — | 1 | - |
| CHEMBL337101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12314 | MESULERGINE | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL39 | SEROTONIN | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL342690 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL136108 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL136978 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL337101 | — | Ki | < | 10000.0 | nM | - |