Assay Detail
Binding
CHEMBL617508
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Binding affinity against human 5-hydroxytryptamine 2C receptor using displacement of [3H]DOB
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.23 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318639 | — | — | 1 | 9.40 |
| CHEMBL414163 | — | — | 1 | 9.00 |
| CHEMBL40726 | — | — | 1 | 9.00 |
| CHEMBL2114265 | — | — | 1 | 9.00 |
| CHEMBL76781 | — | — | 1 | 8.90 |
| CHEMBL2115254 | — | — | 1 | 8.90 |
| CHEMBL2114266 | — | — | 1 | 8.90 |
| CHEMBL313856 | — | — | 1 | 8.70 |
| CHEMBL93154 | — | — | 1 | 8.50 |
| CHEMBL328761 | — | — | 1 | 8.50 |
| CHEMBL92656 | — | — | 1 | 8.40 |
| CHEMBL276673 | — | — | 1 | 8.40 |
| CHEMBL91855 | — | — | 1 | 8.40 |
| CHEMBL2115252 | — | — | 1 | 8.40 |
| CHEMBL320145 | — | — | 1 | 8.40 |
| CHEMBL3350300 | — | — | 1 | 8.40 |
| CHEMBL94272 | — | — | 1 | 8.30 |
| CHEMBL317677 | — | — | 1 | 8.20 |
| CHEMBL96883 | — | — | 1 | 8.20 |
| CHEMBL328844 | — | — | 1 | 8.10 |
| CHEMBL92565 | — | — | 1 | 8.10 |
| CHEMBL96312 | — | — | 1 | 8.10 |
| CHEMBL574985 | — | — | 1 | 8.00 |
| CHEMBL96816 | — | — | 1 | 8.00 |
| CHEMBL96876 | — | — | 1 | 7.90 |
| CHEMBL273304 | — | — | 1 | 7.90 |
| CHEMBL92040 | — | — | 1 | 7.80 |
| CHEMBL93850 | — | — | 1 | 7.20 |
| CHEMBL319998 | — | — | 1 | 7.00 |
| CHEMBL96095 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318639 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL414163 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL40726 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2114265 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL76781 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL2115254 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL2114266 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL313856 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL93154 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL328761 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL92656 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL276673 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL91855 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL2115252 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL320145 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL3350300 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL94272 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL317677 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL96883 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL96312 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL92565 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL328844 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL574985 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL96816 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL96876 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL273304 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL92040 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL93850 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL319998 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL96095 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL317564 | — | Ki | = | 794.33 | nM | 6.10 |