Compound Detail
CHEMBL96095
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Basic Information
| ChEMBL ID | CHEMBL96095 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RMVMBPYOHHFMEV-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
204.3
MW (Da)
2.00
ALogP
3
HBA
1
HBD
40.2
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.9
Ki 1 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.9 | 6.9 | 125.9 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL324 | EC50 | 4.9 | 4.9 | 12589.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Ki | = | 125.89 | nM | 6.9 | Binding affinity against human 5-hydroxytryptamine 2C receptor using displacemen... | 9276022 |
| 5-hydroxytryptamine receptor 2C | EC50 | = | 12589.25 | nM | 4.9 | Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 f... | 9276022 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9276022 | 10.1021/jm970030l | 5-hydroxytryptamine receptor 2C | 4 |
Data from ChEMBL 36 via Core Engine