Assay Detail
Functional
CHEMBL798103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Choroid plexus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.01 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318639 | — | — | 1 | 7.00 |
| CHEMBL2115252 | — | — | 1 | 6.90 |
| CHEMBL96816 | — | — | 1 | 6.80 |
| CHEMBL94272 | — | — | 1 | 6.70 |
| CHEMBL328761 | — | — | 1 | 6.70 |
| CHEMBL76781 | — | — | 1 | 6.70 |
| CHEMBL40726 | — | — | 1 | 6.70 |
| CHEMBL2114265 | — | — | 1 | 6.60 |
| CHEMBL2114266 | — | — | 1 | 6.50 |
| CHEMBL414163 | — | — | 1 | 6.40 |
| CHEMBL313856 | — | — | 1 | 6.40 |
| CHEMBL96312 | — | — | 1 | 6.30 |
| CHEMBL93154 | — | — | 1 | 6.20 |
| CHEMBL92656 | — | — | 1 | 6.20 |
| CHEMBL2115254 | — | — | 1 | 6.10 |
| CHEMBL92565 | — | — | 1 | 5.90 |
| CHEMBL96883 | — | — | 1 | 5.80 |
| CHEMBL273304 | — | — | 1 | 5.70 |
| CHEMBL328844 | — | — | 1 | 5.70 |
| CHEMBL276673 | — | — | 1 | 5.70 |
| CHEMBL91855 | — | — | 1 | 5.60 |
| CHEMBL93850 | — | — | 1 | 5.60 |
| CHEMBL317677 | — | — | 1 | 5.60 |
| CHEMBL320145 | — | — | 1 | 5.60 |
| CHEMBL574985 | — | — | 1 | 5.50 |
| CHEMBL96876 | — | — | 1 | 5.20 |
| CHEMBL92040 | — | — | 1 | 5.10 |
| CHEMBL3350300 | — | — | 1 | 5.10 |
| CHEMBL317564 | — | — | 1 | 5.00 |
| CHEMBL96095 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318639 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2115252 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL96816 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL94272 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL328761 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL76781 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL40726 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2114265 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL2114266 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL414163 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL313856 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL96312 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL93154 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL92656 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL2115254 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL92565 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL96883 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL273304 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL328844 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL276673 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL91855 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL93850 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL317677 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL320145 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL574985 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL96876 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL92040 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3350300 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL317564 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL96095 | — | EC50 | = | 12589.25 | nM | 4.90 |