Assay Detail
Binding
CHEMBL617539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of [3H]ketanserin towards 5-hydroxytryptamine 2 receptor in cloned mammalian receptor expressed in cultured cells or from rat whole brain.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.79 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83915 | — | — | 1 | 8.68 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.42 |
| CHEMBL81330 | — | — | 1 | 8.24 |
| CHEMBL309730 | — | — | 1 | 7.55 |
| CHEMBL82591 | — | — | 1 | 7.52 |
| CHEMBL71724 | — | — | 1 | 7.12 |
| CHEMBL63329 | — | — | 1 | 7.03 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83915 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL42 | CLOZAPINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL81330 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL309730 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL82591 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL71724 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL63329 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 1800.0 | nM | - |