Assay Detail
Binding
CHEMBL617565
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Binding activity against 5-hydroxytryptamine 1D receptor from pig caudate membrane using [3H]5-HT as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.84 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39317 | L-694247 | — | 1 | 9.50 |
| CHEMBL18840 | — | — | 1 | 8.40 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.00 |
| CHEMBL51108 | — | — | 1 | 6.70 |
| CHEMBL298974 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39317 | L-694247 | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL18840 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL39 | SEROTONIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL51108 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL298974 | — | IC50 | = | 251.19 | nM | 6.60 |