Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL617570

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of radioligand [3H]5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membrane
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1D (CHEMBL4105)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
Street LJ, Baker R, Castro JL, Chambers MS, Guiblin AR, Hobbs SC, Matassa VG, Reeve AJ, Beer MS, Middlemiss DN.
J Med Chem (1993) 36 : 1529 -1538
PubMed 8496922 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 8.16 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39435 1 9.60
CHEMBL39317 L-694247 1 9.50
CHEMBL289489 1 9.30
CHEMBL39331 1 9.10
CHEMBL288880 1 9.10
CHEMBL262652 1 8.90
CHEMBL40126 1 8.90
CHEMBL37629 1 8.80
CHEMBL38104 1 8.70
CHEMBL37462 1 8.70
CHEMBL39158 1 8.60
CHEMBL290706 1 8.50
CHEMBL18840 1 8.40
CHEMBL288961 1 8.30
CHEMBL39636 1 8.30
CHEMBL288821 1 8.20
CHEMBL290657 1 8.20
CHEMBL38738 1 8.10
CHEMBL38482 1 8.10
CHEMBL38671 1 8.00
CHEMBL36497 1 8.00
CHEMBL39111 1 8.00
CHEMBL39 SEROTONIN 3.0 1 8.00
CHEMBL289354 1 7.90
CHEMBL290587 1 7.90
CHEMBL440848 1 7.90
CHEMBL38503 1 7.90
CHEMBL290080 1 7.80
CHEMBL37317 1 7.70
CHEMBL37123 1 7.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39435 IC50 = 0.2512 nM 9.60
CHEMBL39317 L-694247 IC50 = 0.3162 nM 9.50
CHEMBL289489 IC50 = 0.5012 nM 9.30
CHEMBL39331 IC50 = 0.7943 nM 9.10
CHEMBL288880 IC50 = 0.7943 nM 9.10
CHEMBL262652 IC50 = 1.259 nM 8.90
CHEMBL40126 IC50 = 1.259 nM 8.90
CHEMBL37629 IC50 = 1.585 nM 8.80
CHEMBL38104 IC50 = 1.995 nM 8.70
CHEMBL37462 IC50 = 1.995 nM 8.70
CHEMBL39158 IC50 = 2.512 nM 8.60
CHEMBL290706 IC50 = 3.162 nM 8.50
CHEMBL18840 IC50 = 3.981 nM 8.40
CHEMBL288961 IC50 = 5.012 nM 8.30
CHEMBL39636 IC50 = 5.012 nM 8.30
CHEMBL288821 IC50 = 6.31 nM 8.20
CHEMBL290657 IC50 = 6.31 nM 8.20
CHEMBL38738 IC50 = 7.943 nM 8.10
CHEMBL38482 IC50 = 7.943 nM 8.10
CHEMBL39 SEROTONIN IC50 = 10.0 nM 8.00
CHEMBL36497 IC50 = 10.0 nM 8.00
CHEMBL38671 IC50 = 10.0 nM 8.00
CHEMBL39111 IC50 = 10.0 nM 8.00
CHEMBL289354 IC50 = 12.59 nM 7.90
CHEMBL290587 IC50 = 12.59 nM 7.90
CHEMBL440848 IC50 = 12.59 nM 7.90
CHEMBL38503 IC50 = 12.59 nM 7.90
CHEMBL290080 IC50 = 15.85 nM 7.80
CHEMBL290171 IC50 = 19.95 nM 7.70
CHEMBL128 SUMATRIPTAN IC50 = 19.95 nM 7.70
CHEMBL37123 IC50 = 19.95 nM 7.70
CHEMBL37317 IC50 = 19.95 nM 7.70
CHEMBL39243 IC50 = 25.12 nM 7.60
CHEMBL289936 IC50 = 31.62 nM 7.50
CHEMBL39712 IC50 = 31.62 nM 7.50
CHEMBL39801 IC50 = 31.62 nM 7.50
CHEMBL39296 IC50 = 50.12 nM 7.30
CHEMBL289501 IC50 = 50.12 nM 7.30
CHEMBL35875 IC50 = 79.43 nM 7.10
CHEMBL434974 IC50 = 79.43 nM 7.10