Assay Detail
Binding
CHEMBL617579
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Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1D (CHEMBL5450) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.52 |
| CHEMBL83597 | — | — | 1 | 8.51 |
| CHEMBL84107 | — | — | 1 | 8.21 |
| CHEMBL314213 | — | — | 1 | 8.00 |
| CHEMBL84942 | — | — | 1 | 7.82 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL83597 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL84107 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL314213 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL84942 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL128 | SUMATRIPTAN | IC50 | = | 61.0 | nM | 7.21 |