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Assay Detail

CHEMBL617599

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro affinity human cloned 5-hydroxytryptamine 1D receptor alpha by [3H]5-HT displacement.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1D (CHEMBL1983)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors.
Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C.
J Med Chem (1996) 39 : 314 -322
PubMed 8568822 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.43 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111376 1 8.82
CHEMBL326667 1 8.80
CHEMBL39 SEROTONIN 3.0 1 8.77
CHEMBL320079 1 8.31
CHEMBL111150 1 7.80
CHEMBL111284 1 7.38
CHEMBL322054 1 7.38
CHEMBL111283 1 7.38
CHEMBL110318 1 7.26
CHEMBL6640 TRYPTAMINE 1 7.21
CHEMBL109839 1 7.16
CHEMBL414420 1 6.68
CHEMBL418823 1 6.65
CHEMBL108818 1 5.96
CHEMBL108337 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111376 Ki = 1.5 nM 8.82
CHEMBL326667 Ki = 1.6 nM 8.80
CHEMBL39 SEROTONIN Ki = 1.7 nM 8.77
CHEMBL320079 Ki = 4.9 nM 8.31
CHEMBL111150 Ki = 16.0 nM 7.80
CHEMBL111284 Ki = 42.0 nM 7.38
CHEMBL322054 Ki = 42.0 nM 7.38
CHEMBL111283 Ki = 42.0 nM 7.38
CHEMBL110318 Ki = 55.0 nM 7.26
CHEMBL6640 TRYPTAMINE Ki = 61.0 nM 7.21
CHEMBL109839 Ki = 69.0 nM 7.16
CHEMBL414420 Ki = 210.0 nM 6.68
CHEMBL418823 Ki = 223.0 nM 6.65
CHEMBL108818 Ki = 1098.0 nM 5.96
CHEMBL108337 Ki = 1190.0 nM 5.92