Assay Detail
Functional
CHEMBL617618
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Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.53 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323356 | — | — | 1 | 7.95 |
| CHEMBL172269 | — | — | 1 | 7.82 |
| CHEMBL536255 | — | — | 1 | 7.41 |
| CHEMBL354951 | — | — | 1 | 7.33 |
| CHEMBL422923 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323356 | — | Kd | = | 11.22 | nM | 7.95 |
| CHEMBL172269 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL536255 | — | Kd | = | 38.9 | nM | 7.41 |
| CHEMBL354951 | — | Kd | = | 46.77 | nM | 7.33 |
| CHEMBL422923 | — | Kd | = | 69.18 | nM | 7.16 |