Assay Detail
Binding
CHEMBL617674
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Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortical regions using [3H]ketanserin as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.00 |
| CHEMBL79834 | SPIRAMIDE | 2.0 | 1 | 8.70 |
| CHEMBL316004 | LENPERONE | 2.0 | 1 | 8.40 |
| CHEMBL314702 | — | — | 1 | 8.30 |
| CHEMBL84542 | — | — | 1 | 8.30 |
| CHEMBL86072 | — | — | 1 | 8.10 |
| CHEMBL419848 | — | — | 1 | 7.52 |
| CHEMBL315522 | — | — | 1 | 7.50 |
| CHEMBL314430 | — | — | 1 | 7.47 |
| CHEMBL82688 | — | — | 1 | 7.30 |
| CHEMBL85954 | — | — | 1 | 7.16 |
| CHEMBL85508 | — | — | 1 | 7.16 |
| CHEMBL83867 | — | — | 1 | 7.10 |
| CHEMBL85507 | — | — | 1 | 7.06 |
| CHEMBL313337 | — | — | 1 | 7.02 |
| CHEMBL82519 | PRIMAPERONE | 2.0 | 1 | 6.85 |
| CHEMBL309484 | — | — | 1 | 6.64 |
| CHEMBL85392 | — | — | 1 | 6.53 |
| CHEMBL82436 | — | — | 1 | 6.49 |
| CHEMBL84079 | — | — | 1 | 6.24 |
| CHEMBL309992 | — | — | 1 | 6.22 |
| CHEMBL81959 | — | — | 1 | 6.00 |
| CHEMBL82565 | — | — | 1 | 5.85 |
| CHEMBL82567 | — | — | 1 | - |
| CHEMBL309711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL79834 | SPIRAMIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL316004 | LENPERONE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL314702 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL84542 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL86072 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL419848 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL315522 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL314430 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL82688 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL85954 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL85508 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL83867 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL85507 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL313337 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL82519 | PRIMAPERONE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL309484 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL85392 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL82436 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL84079 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL309992 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL81959 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL82565 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL82567 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL309711 | — | Ki | > | 10000.0 | nM | - |