Compound Detail
CHEMBL316004
LENPERONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL316004 |
| Name | LENPERONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WCIBOXFOUGQLFC-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
4
Known Names
Molecular Properties
371.4
MW (Da)
4.52
ALogP
3
HBA
0
HBD
37.4
PSA (Ų)
0.67
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 5 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor CHEMBL2093870 | Ki | 8.4 | 8.385 | 4.0 | 2 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.52 | 6.52 | 305.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL324 | Ki | 6.46 | 6.46 | 345.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor | Ki | = | 4.0 | nM | 8.4 | Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat fron... | 8355253 |
| Serotonin 2 (5-HT2) receptor | Ki | = | 4.3 | nM | 8.37 | Binding affinity against 5-hydroxytryptamine 2 receptor in rat using [3H]ketanse... | 1479590 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 305.0 | nM | 6.52 | Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat fro... | 8355253 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 345.0 | nM | 6.46 | Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat fro... | 8355253 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 345.0 | nM | 6.46 | Binding affinity against 5-hydroxytryptamine 1C receptor in rat using [3H]mesule... | 1479590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 8355253 | 10.1021/jm00069a010 | Serotonin 2 (5-HT2) receptor | 2 |
| 1479590 | 10.1021/jm00104a017 | Serotonin 2 (5-HT2) receptor | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 8355253 | 10.1021/jm00069a010 | 5-hydroxytryptamine receptor 1A | 1 |
| 8355253 | 10.1021/jm00069a010 | 5-hydroxytryptamine receptor 2C | 1 |
| 1479590 | 10.1021/jm00104a017 | 5-hydroxytryptamine receptor 2C | 1 |
Data from ChEMBL 36 via Core Engine