Assay Detail
Binding
CHEMBL616836
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Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat frontal cortical regions using [3H]mesulergine as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.72 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86072 | — | — | 1 | 6.47 |
| CHEMBL316004 | LENPERONE | 2.0 | 1 | 6.46 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.00 |
| CHEMBL82688 | — | — | 1 | 5.78 |
| CHEMBL314430 | — | — | 1 | 5.64 |
| CHEMBL315522 | — | — | 1 | 5.54 |
| CHEMBL84542 | — | — | 1 | 5.50 |
| CHEMBL83867 | — | — | 1 | 5.48 |
| CHEMBL85507 | — | — | 1 | 5.44 |
| CHEMBL79834 | SPIRAMIDE | 2.0 | 1 | 5.37 |
| CHEMBL84079 | — | — | 1 | 5.22 |
| CHEMBL85954 | — | — | 1 | - |
| CHEMBL309484 | — | — | 1 | - |
| CHEMBL82567 | — | — | 1 | - |
| CHEMBL314702 | — | — | 1 | - |
| CHEMBL82565 | — | — | 1 | - |
| CHEMBL85392 | — | — | 1 | - |
| CHEMBL82436 | — | — | 1 | - |
| CHEMBL82519 | PRIMAPERONE | 2.0 | 1 | - |
| CHEMBL81959 | — | — | 1 | - |
| CHEMBL309711 | — | — | 1 | - |
| CHEMBL313337 | — | — | 1 | - |
| CHEMBL419848 | — | — | 1 | - |
| CHEMBL309992 | — | — | 1 | - |
| CHEMBL85508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86072 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL316004 | LENPERONE | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL267930 | SPIPERONE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL82688 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL314430 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL315522 | — | Ki | = | 2870.0 | nM | 5.54 |
| CHEMBL84542 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL83867 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL85507 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL79834 | SPIRAMIDE | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL84079 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL85954 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL309484 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL82567 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL314702 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL82565 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL85392 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL82436 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL82519 | PRIMAPERONE | Ki | > | 10000.0 | nM | - |
| CHEMBL81959 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL309711 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL313337 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL419848 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL309992 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL85508 | — | Ki | > | 10000.0 | nM | - |