Assay Detail
Binding
CHEMBL617681
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The ability to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.30 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 8.21 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 6.38 |
| CHEMBL38041 | — | — | 1 | - |
| CHEMBL296522 | RENZAPRIDE | 3.0 | 1 | - |
| CHEMBL1907770 | — | — | 1 | - |
| CHEMBL34291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL38041 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL296522 | RENZAPRIDE | Ki | > | 10000.0 | nM | - |
| CHEMBL1907770 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL34291 | — | Ki | > | 10000.0 | nM | - |