Compound Detail
CHEMBL1907770
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Basic Information
| ChEMBL ID | CHEMBL1907770 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQZUPPBUGNMRJI-HKJQSTPSSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
307.8
MW (Da)
1.36
ALogP
4
HBA
2
HBD
67.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 9.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor CHEMBL2094116 | Ki | 9.64 | 9.64 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor | Ki | = | 0.23 | nM | 9.64 | Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor | 1573641 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1573641 | 10.1021/jm00086a019 | 5-hydroxytryptamine receptor 4 | 1 |
| 1573641 | 10.1021/jm00086a019 | Serotonin 3 (5-HT3) receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | Unchecked | 1 |
| 1573641 | 10.1021/jm00086a019 | Serotonin 1 (5-HT1) receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | Serotonin 2 (5-HT2) receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | D(1A) dopamine receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | D(2) dopamine receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | Alpha-1A adrenergic receptor | 1 |
| 1573641 | 10.1021/jm00086a019 | Adrenergic receptor alpha-2 | 1 |
| 1573641 | 10.1021/jm00086a019 | Adrenergic receptor beta | 1 |
Data from ChEMBL 36 via Core Engine