Serotonin 3 (5-HT3) receptor · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P35563. Use UniProt P35563 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35563 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 3A
Review this target as Serotonin 3 (5-HT3) receptor, mapped to UniProt P35563. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 3A. Sequence length is 483 aa.
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This review treats Serotonin 3 (5-HT3) receptor as ChEMBL target CHEMBL2094116, mapped to UniProt P35563. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serotonin 3 (5-HT3) receptor |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P35563 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 3A |
| UniProt Accession | P35563 |
| Component Type | Protein |
| Sequence Length | 483 aa |
5-hydroxytryptamine receptor 3A
Review this target as Serotonin 3 (5-HT3) receptor, mapped to UniProt P35563. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 3A. Sequence length is 483 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL289469 | 10.6 | Kd | 0.02512 | Approved |
| CHEMBL111448 | 10.49 | Ki | 0.032 | Preclinical |
| CHEMBL1160926 | 10.42 | Ki | 0.038 | Preclinical |
| CHEMBL1720 | 10.4 | Ki | 0.03981 | Approved |
| CHEMBL64078 | 10.15 | Ki | 0.07079 | Preclinical |
| CHEMBL333737 | 10.12 | Ki | 0.075 | Preclinical |
| CHEMBL439857 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL43355 | 10.01 | Ki | 0.09772 | Preclinical |
| CHEMBL64279 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL91147 | 10.0 | Ki | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 43 | 307 | 7.8 |
| protein complex format | 30 | 121 | 7.5 |
| cell membrane format | 23 | 248 | 7.8 |
| tissue-based format | 16 | 150 | 7.9 |
| cell-based format | 4 | 15 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 67 | 0 | — |
| assay format | 33 | 72 | 7.9 |
| tissue-based format | 8 | 9 | 7.5 |
| cell-based format | 1 | 1 | 5.3 |