Compound Detail
CHEMBL1720
PALONOSETRON HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1720 |
| Name | PALONOSETRON HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | OLDRWYVIKMSFFB-SSPJITILSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1189679 |
| Active Moiety | CHEMBL1189679 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
10
Known Names
6
Indications
1
Mechanisms
Molecular Properties
296.4
MW (Da)
2.66
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2003 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serotonin 3a (5-HT3a) receptor antagonist | ANTAGONIST | 5-hydroxytryptamine receptor 3A | ✓ | ✓ |
Indications
Nausea Nausea Neoplasms Postoperative Nausea and Vomiting Postoperative Nausea and Vomiting Vomiting
Activity Summary
Ki 1 meas. best 10.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor CHEMBL2094116 | Ki | 10.4 | 10.4 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 3 (5-HT3) receptor | Ki | = | 0.03981 | nM | 10.4 | Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cor... | 8410977 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8410977 | 10.1021/jm00070a008 | Mustela putorius furo | 10 |
| 8410977 | 10.1021/jm00070a008 | Canis familiaris | 10 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 9 |
| - | 10.6019/CHEMBL5303304 | U2OS | 4 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL5665443 | Uracil-DNA glycosylase | 1 |
| - | 10.6019/CHEMBL5665443 | Methyl-CpG-binding domain protein 4 | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| 8410977 | 10.1021/jm00070a008 | Serotonin 3 (5-HT3) receptor | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine