Assay Detail
Binding
CHEMBL617698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.84 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327197 | — | — | 1 | 9.43 |
| CHEMBL124886 | — | — | 1 | 9.36 |
| CHEMBL341474 | — | — | 1 | 9.09 |
| CHEMBL331304 | — | — | 1 | 8.41 |
| CHEMBL120216 | — | — | 1 | 8.27 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 8.21 |
| CHEMBL122835 | — | — | 1 | 8.05 |
| CHEMBL120215 | — | — | 1 | 8.02 |
| CHEMBL121076 | — | — | 1 | 7.96 |
| CHEMBL123137 | — | — | 1 | 7.66 |
| CHEMBL121155 | — | — | 1 | 7.66 |
| CHEMBL121687 | — | — | 1 | 7.55 |
| CHEMBL421059 | — | — | 1 | 7.29 |
| CHEMBL332328 | — | — | 1 | 7.09 |
| CHEMBL126041 | — | — | 1 | 7.06 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.14 |
| CHEMBL266591 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327197 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL124886 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL341474 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL331304 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL120216 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL18772 | QUIPAZINE | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL122835 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL120215 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL121076 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL123137 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL121155 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL121687 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL421059 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL332328 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL126041 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL39 | SEROTONIN | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL266591 | — | IC50 | = | 779.0 | nM | 6.11 |