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Assay Detail

CHEMBL617702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-LY 278584 as radioligand
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Serotonin 3 (5-HT3) receptor (CHEMBL2094116)
Type PROTEIN COMPLEX
Organism Rattus norvegicus

Publication

2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
Tapia I, Alonso-Cires L, López-Tudanca PL, Mosquera R, Labeaga L, Innerárity A, Orjales A.
J Med Chem (1999) 42 : 2870 -2880
PubMed 10425096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 6.57 7.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL317146 1 7.13
CHEMBL100088 1 6.00
CHEMBL317277 1 -
CHEMBL99452 1 -
CHEMBL99590 1 -
CHEMBL99723 1 -
CHEMBL99577 1 -
CHEMBL97755 1 -
CHEMBL99147 1 -
CHEMBL318068 1 -
CHEMBL95685 1 -
CHEMBL95808 1 -
CHEMBL97019 1 -
CHEMBL319886 1 -
CHEMBL100199 1 -
CHEMBL418786 1 -
CHEMBL95235 1 -
CHEMBL33884 1 -
CHEMBL321970 1 -
CHEMBL95661 1 -
CHEMBL99578 1 -
CHEMBL318764 1 -
CHEMBL99141 1 -
CHEMBL97903 1 -
CHEMBL100313 1 -
CHEMBL93611 1 -
CHEMBL99096 1 -
CHEMBL99383 1 -
CHEMBL100317 1 -
CHEMBL421187 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL317146 IC50 = 73.9 nM 7.13
CHEMBL100088 IC50 = 1000.0 nM 6.00
CHEMBL95808 IC50 > 1000.0 nM -
CHEMBL97508 IC50 > 1000.0 nM -
CHEMBL95685 IC50 > 1000.0 nM -
CHEMBL318068 IC50 > 1000.0 nM -
CHEMBL99147 IC50 > 1000.0 nM -
CHEMBL97755 IC50 > 1000.0 nM -
CHEMBL99577 IC50 > 1000.0 nM -
CHEMBL99723 IC50 > 1000.0 nM -
CHEMBL99590 IC50 > 1000.0 nM -
CHEMBL99452 IC50 > 1000.0 nM -
CHEMBL317277 IC50 > 1000.0 nM -
CHEMBL328641 IC50 > 1000.0 nM -
CHEMBL95968 IC50 > 1000.0 nM -
CHEMBL99299 IC50 > 1000.0 nM -
CHEMBL99515 IC50 > 1000.0 nM -
CHEMBL418790 IC50 > 1000.0 nM -
CHEMBL99591 IC50 > 1000.0 nM -
CHEMBL318764 IC50 > 1000.0 nM -
CHEMBL421187 IC50 > 1000.0 nM -
CHEMBL100317 IC50 > 1000.0 nM -
CHEMBL99383 IC50 > 1000.0 nM -
CHEMBL99096 IC50 > 1000.0 nM -
CHEMBL93611 IC50 > 1000.0 nM -
CHEMBL100313 IC50 > 1000.0 nM -
CHEMBL97903 IC50 > 1000.0 nM -
CHEMBL99141 IC50 > 1000.0 nM -
CHEMBL97019 IC50 > 1000.0 nM -
CHEMBL99578 IC50 > 1000.0 nM -
CHEMBL95661 IC50 > 1000.0 nM -
CHEMBL321970 IC50 > 1000.0 nM -
CHEMBL33884 IC50 > 1000.0 nM -
CHEMBL95235 IC50 > 1000.0 nM -
CHEMBL418786 IC50 > 1000.0 nM -
CHEMBL100199 IC50 > 1000.0 nM -
CHEMBL319886 IC50 > 1000.0 nM -