Assay Detail
Binding
CHEMBL617706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]BRL-43694 binding to rat 5-hydroxytryptamine 3 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.22 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.34 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 6.05 |
| CHEMBL24909 | — | — | 1 | 6.02 |
| CHEMBL282234 | — | — | 1 | 5.48 |
| CHEMBL27395 | — | — | 1 | - |
| CHEMBL27054 | — | — | 1 | - |
| CHEMBL25396 | — | — | 1 | - |
| CHEMBL26700 | — | — | 1 | - |
| CHEMBL27896 | — | — | 1 | - |
| CHEMBL24895 | — | — | 1 | - |
| CHEMBL24854 | — | — | 1 | - |
| CHEMBL281123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1729 | CISAPRIDE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL24909 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL282234 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL27395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL27054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL25396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26700 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL27896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL24895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL24854 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL281123 | — | IC50 | > | 100000.0 | nM | - |