Assay Detail
Binding
CHEMBL617805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]GR-65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40903 | — | — | 1 | 9.00 |
| CHEMBL416047 | — | — | 1 | 8.96 |
| CHEMBL40497 | — | — | 1 | 8.92 |
| CHEMBL39016 | — | — | 1 | 8.89 |
| CHEMBL38969 | — | — | 1 | 8.80 |
| CHEMBL38473 | — | — | 1 | 8.70 |
| CHEMBL432284 | — | — | 1 | 8.68 |
| CHEMBL40082 | — | — | 1 | 8.54 |
| CHEMBL287760 | — | — | 1 | 8.42 |
| CHEMBL290959 | — | — | 1 | 8.29 |
| CHEMBL291296 | — | — | 1 | 8.00 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40903 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL416047 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL40497 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL39016 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL38969 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL38473 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL432284 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL40082 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL287760 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL290959 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL291296 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 880.0 | nM | 6.06 |