Assay Detail
Binding
CHEMBL617806
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Binding affinity was evaluated in vitro by displacement of [3H]zacopride radioligand from 5-hydroxytryptamine 3 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Azaheteroaromatic ethers as carbonyl bioisosteres. Synthesis and evaluation of a novel class of 5-HT3 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.96 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 8.66 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.64 |
| CHEMBL82138 | — | — | 1 | 8.16 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 8.15 |
| CHEMBL84290 | — | — | 1 | 7.40 |
| CHEMBL2107804 | BEMESETRON | 2.0 | 1 | 7.37 |
| CHEMBL310107 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL56564 | TROPISETRON | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL82138 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL46 | ONDANSETRON | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL84290 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL2107804 | BEMESETRON | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL310107 | — | IC50 | = | 48.0 | nM | 7.32 |