Assay Detail
Binding
CHEMBL617838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.31 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.38 |
| CHEMBL341474 | — | — | 1 | 6.38 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.33 |
| CHEMBL327197 | — | — | 1 | 6.11 |
| CHEMBL331304 | — | — | 1 | 6.11 |
| CHEMBL120216 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL341474 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL18772 | QUIPAZINE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL327197 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL331304 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL120216 | — | IC50 | = | 2803.0 | nM | 5.55 |