Assay Detail
Binding
CHEMBL617844
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Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542029 | — | — | 1 | 8.15 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.10 |
| CHEMBL554670 | — | — | 1 | 7.85 |
| CHEMBL555362 | — | — | 1 | 7.34 |
| CHEMBL544184 | — | — | 1 | 7.05 |
| CHEMBL163239 | — | — | 1 | 5.92 |
| CHEMBL94067 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542029 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL42 | CLOZAPINE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL554670 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL555362 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL544184 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL163239 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL94067 | — | Ki | = | 1500.0 | nM | 5.82 |