Assay Detail
Binding
CHEMBL617853
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Binding affinity towards 5-HT 2C receptor in rat stomach fundus
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Stomach |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.13 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96485 | — | — | 1 | 9.02 |
| CHEMBL319009 | — | — | 1 | 8.69 |
| CHEMBL1202891 | — | — | 1 | 8.68 |
| CHEMBL96480 | — | — | 1 | 8.51 |
| CHEMBL96782 | — | — | 1 | 8.11 |
| CHEMBL96559 | — | — | 1 | 7.92 |
| CHEMBL94644 | — | — | 1 | 7.73 |
| CHEMBL95121 | — | — | 1 | 7.61 |
| CHEMBL323330 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96485 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL319009 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL1202891 | — | Ki | = | 2.089 | nM | 8.68 |
| CHEMBL96480 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL96782 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL96559 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL94644 | — | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL95121 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL323330 | — | Ki | = | 125.89 | nM | 6.90 |