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Assay Detail

CHEMBL617869

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]GR-113808 from 5-hydroxytryptamine 4 receptor in guinea pig striatum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

5-hydroxytryptamine receptor 4 (CHEMBL5017)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
Tapia I, Alonso-Cires L, López-Tudanca PL, Mosquera R, Labeaga L, Innerárity A, Orjales A.
J Med Chem (1999) 42 : 2870 -2880
PubMed 10425096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99577 1 6.00
CHEMBL95685 1 -
CHEMBL318068 1 -
CHEMBL317377 1 -
CHEMBL317277 1 -
CHEMBL96960 1 -
CHEMBL328641 1 -
CHEMBL418790 1 -
CHEMBL99383 1 -
CHEMBL99096 1 -
CHEMBL100313 1 -
CHEMBL321970 1 -
CHEMBL418786 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99577 IC50 = 1000.0 nM 6.00
CHEMBL95685 IC50 > 1000.0 nM -
CHEMBL318068 IC50 > 1000.0 nM -
CHEMBL317377 IC50 > 1000.0 nM -
CHEMBL317277 IC50 > 1000.0 nM -
CHEMBL96960 IC50 > 1000.0 nM -
CHEMBL328641 IC50 > 1000.0 nM -
CHEMBL418790 IC50 > 1000.0 nM -
CHEMBL99383 IC50 > 1000.0 nM -
CHEMBL99096 IC50 > 1000.0 nM -
CHEMBL100313 IC50 > 1000.0 nM -
CHEMBL321970 IC50 > 1000.0 nM -
CHEMBL418786 IC50 > 1000.0 nM -