Assay Detail
Binding
CHEMBL617981
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In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.97 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19006 | — | — | 1 | 9.54 |
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 9.38 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.89 |
| CHEMBL18274 | — | — | 1 | 8.43 |
| CHEMBL19039 | — | — | 1 | 8.31 |
| CHEMBL279850 | — | — | 1 | 8.21 |
| CHEMBL416172 | — | — | 1 | 8.03 |
| CHEMBL18769 | — | — | 1 | 7.53 |
| CHEMBL277543 | — | — | 1 | 6.89 |
| CHEMBL18473 | — | — | 1 | 6.84 |
| CHEMBL19022 | — | — | 1 | 6.81 |
| CHEMBL275356 | — | — | 1 | 6.73 |
| CHEMBL279823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19006 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL18041 | ZACOPRIDE | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL56564 | TROPISETRON | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL18274 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL19039 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL279850 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL416172 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL18769 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL277543 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL18473 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL19022 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL275356 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL279823 | — | Ki | > | 1000.0 | nM | - |