Assay Detail
Binding
CHEMBL617984
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In vitro displacement of [3H]ICS-205-930 from 5-hydroxytryptamine 3 receptor in cultured NG-108-15 rat glioma cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.90 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289060 | — | — | 1 | 9.00 |
| CHEMBL38465 | — | — | 1 | 8.82 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.57 |
| CHEMBL40260 | — | — | 1 | 8.48 |
| CHEMBL290938 | — | — | 1 | 7.98 |
| CHEMBL41077 | — | — | 1 | 7.85 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.79 |
| CHEMBL288435 | — | — | 1 | 6.65 |
| CHEMBL266591 | — | — | 1 | 5.92 |
| CHEMBL290266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289060 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL38465 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL56564 | TROPISETRON | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL40260 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL290938 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL41077 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL46 | ONDANSETRON | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL288435 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL266591 | — | Ki | = | 1217.0 | nM | 5.92 |
| CHEMBL290266 | — | Ki | > | 1000.0 | nM | - |