Assay Detail
Binding
CHEMBL618050
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In vitro inhibitory activity against 5-Lipoxygenase in rat by Peritoneal 5-lipoxygenase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93598 | — | — | 1 | 6.10 |
| CHEMBL93670 | — | — | 1 | 6.10 |
| CHEMBL93599 | — | — | 1 | 5.70 |
| CHEMBL329606 | — | — | 1 | 5.70 |
| CHEMBL316996 | — | — | 1 | 5.70 |
| CHEMBL92299 | — | — | 1 | 5.30 |
| CHEMBL432054 | — | — | 1 | - |
| CHEMBL94220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93598 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL93670 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL93599 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL329606 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL316996 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL92299 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL432054 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL94220 | — | IC50 | > | 50000.0 | nM | - |