Assay Detail
Binding
CHEMBL618055
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In vitro inhibitory activity against 5-lipoxygenase in rat RBL-1 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.29 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65654 | — | — | 1 | 7.22 |
| CHEMBL63882 | — | — | 1 | 7.00 |
| CHEMBL65655 | — | — | 1 | 6.66 |
| CHEMBL69110 | — | — | 1 | 6.55 |
| CHEMBL304443 | — | — | 1 | 6.54 |
| CHEMBL67411 | — | — | 1 | 6.39 |
| CHEMBL303033 | — | — | 1 | 6.14 |
| CHEMBL65430 | — | — | 1 | 6.01 |
| CHEMBL302754 | — | — | 1 | 5.89 |
| CHEMBL65946 | — | — | 1 | 5.43 |
| CHEMBL292707 | IBUPROXAM | 2.0 | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65654 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL63882 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL65655 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL69110 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL304443 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL67411 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL303033 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL65430 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL302754 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL65946 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL292707 | IBUPROXAM | IC50 | = | 4840.0 | nM | 5.32 |