Assay Detail
Binding
CHEMBL618057
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In vitro inhibitory activity against 5-lipoxygenase was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.03 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54156 | — | — | 1 | 6.13 |
| CHEMBL298672 | — | — | 1 | 6.11 |
| CHEMBL299794 | — | — | 1 | 6.06 |
| CHEMBL50833 | — | — | 1 | 6.00 |
| CHEMBL350729 | — | — | 1 | 6.00 |
| CHEMBL417022 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54156 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL298672 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL299794 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL50833 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL350729 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL417022 | — | IC50 | = | 1390.0 | nM | 5.86 |