Assay Detail
Binding
CHEMBL618059
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Inhibition of 5-lipoxygenase in intact RBL-1 cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.21 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303199 | — | — | 1 | 6.05 |
| CHEMBL65759 | — | — | 1 | 6.00 |
| CHEMBL65430 | — | — | 1 | 5.92 |
| CHEMBL65490 | — | — | 1 | 5.85 |
| CHEMBL65535 | — | — | 1 | 5.82 |
| CHEMBL65050 | — | — | 1 | 5.41 |
| CHEMBL295829 | OXAMETACIN | 2.0 | 1 | 5.12 |
| CHEMBL65299 | — | — | 1 | 4.89 |
| CHEMBL433287 | — | — | 1 | 4.80 |
| CHEMBL292707 | IBUPROXAM | 2.0 | 1 | 4.70 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 4.62 |
| CHEMBL65431 | — | — | 1 | 4.62 |
| CHEMBL65130 | — | — | 1 | 4.62 |
| CHEMBL303307 | — | — | 1 | 4.58 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303199 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL65759 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL65430 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL65490 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL65535 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL65050 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL295829 | OXAMETACIN | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL65299 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL433287 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL292707 | IBUPROXAM | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL65431 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL65130 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL303307 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL15770 | SULINDAC | IC50 | > | 100000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL521 | IBUPROFEN | IC50 | - | nM | - |